Faculty Collaboration Database

KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy. Cancers (Basel) 2025 Feb 25;17(5)

Date

03/13/2025

Pubmed ID

40075634

Pubmed Central ID

PMC11899378

DOI

10.3390/cancers17050785

Scopus ID

2-s2.0-86000633343 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

The Kirsten rat sarcoma viral oncogene homologue (KRAS) mutation is one of the most prevailing mutations in various tumors and is difficult to cure. Long-term proliferation in carcinogenesis is primarily initiated by oncogenic KRAS-downstream signaling. Recent research suggests that it also activates the autocrine effect and interplays the tumor microenvironment (TME). Here, we discuss the emerging research, including KRAS mutations to immune evasion in TME, which induce immunological modulation that promotes tumor development. This review gives an overview of the existing knowledge of the underlying connection between KRAS mutations and tumor immune modulation. It also addresses the mechanisms to reduce the effect of oncogenes on the immune system and recent advances in clinical trials for immunotherapy in KRAS-mutated cancers.

Author List

Uniyal P, Kashyap VK, Behl T, Parashar D, Rawat R

Author

Deepak Parashar PhD Assistant Professor in the Medicine department at Medical College of Wisconsin