Faculty Collaboration Database

Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-alpha and beta-chemokine receptors in congenital CMV disease. J Infect Dis 2002 Oct 15;186(8):1057-64

Date

10/02/2002

Pubmed ID

12355354

DOI

10.1086/344238

Scopus ID

2-s2.0-0037108926 (requires institutional sign-in at Scopus site)   99 Citations

Abstract

Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-alpha-like receptor gene, the US28 beta-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P=.04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P=.864 and P=.765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-alpha-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.

Author List

Arav-Boger R, Willoughby RE, Pass RF, Zong JC, Jang WJ, Alcendor D, Hayward GS

Authors

Ravit Boger MD Chief, Professor in the Pediatrics department at Medical College of Wisconsin
Rodney E. Willoughby MD Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Amino Acid Sequence
Cytomegalovirus
Cytomegalovirus Infections
Female
Genes, Viral
Genotype
Humans
Infant, Newborn
Infant, Newborn, Diseases
Infectious Disease Transmission, Vertical
Membrane Glycoproteins
Molecular Sequence Data
Phylogeny
Polymerase Chain Reaction
Polymorphism, Genetic
Pregnancy
Receptors, Chemokine
Receptors, Tumor Necrosis Factor
Viral Proteins
Virulence