Comparison of candidacidal and candidastatic activities of human neutrophils. Infect Immun 1990 Aug;58(8):2696-8
Date
08/01/1990Pubmed ID
2196230Pubmed Central ID
PMC258877DOI
10.1128/iai.58.8.2696-2698.1990Scopus ID
2-s2.0-0025286410 (requires institutional sign-in at Scopus site) 14 CitationsAbstract
Disruption of neutrophils causes the release of a cytoplasmic protein which can inhibit the growth of Candida albicans without killing the organisms. The present study was undertaken with a combined system in which candidacidal and candidastatic activities of human neutrophils could be compared. In this system it was found that disruption of either half or all of the neutrophils in the samples markedly improved the ability of the cells to handle an inoculum of Candida yeast cells over a 48-h period, even though the disrupted cells had primarily candidastatic activity, with very little candidacidal activity.
Author List
Sohnle PG, Collins-Lech CAuthor
Peter G. Sohnle MS, MD Emeritus Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Candida albicansCell Fractionation
Colony Count, Microbial
Cytoplasm
Humans
Neutrophils
