Water sensor ppk28 modulates Drosophila lifespan and physiology through AKH signaling. Proc Natl Acad Sci U S A 2014 Jun 03;111(22):8137-42
Date
05/14/2014Pubmed ID
24821805Pubmed Central ID
PMC4050545DOI
10.1073/pnas.1315461111Scopus ID
2-s2.0-84901824353 (requires institutional sign-in at Scopus site) 77 CitationsAbstract
Sensory perception modulates lifespan across taxa, presumably due to alterations in physiological homeostasis after central nervous system integration. The coordinating circuitry of this control, however, remains unknown. Here, we used the Drosophila melanogaster gustatory system to dissect one component of sensory regulation of aging. We found that loss of the critical water sensor, pickpocket 28 (ppk28), altered metabolic homeostasis to promote internal lipid and water stores and extended healthy lifespan. Additionally, loss of ppk28 increased neuronal glucagon-like adipokinetic hormone (AKH) signaling, and the AKH receptor was necessary for ppk28 mutant effects. Furthermore, activation of AKH-producing cells alone was sufficient to enhance longevity, suggesting that a perceived lack of water availability triggers a metabolic shift that promotes the production of metabolic water and increases lifespan via AKH signaling. This work provides an example of how discrete gustatory signals recruit nutrient-dependent endocrine systems to coordinate metabolic homeostasis, thereby influencing long-term health and aging.
Author List
Waterson MJ, Chung BY, Harvanek ZM, Ostojic I, Alcedo J, Pletcher SDAuthor
Brian Y. Chung PhD Assistant Professor in the Cancer Center department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAnimals
Animals, Genetically Modified
Drosophila Proteins
Drosophila melanogaster
Epithelial Sodium Channels
Female
Food
Homeostasis
Insect Hormones
Longevity
Male
Neuroendocrine Cells
Oligopeptides
Pyrrolidonecarboxylic Acid
Receptors, Glucagon
Signal Transduction
Taste
Water
