Medical College of Wisconsin
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The effect of platelet inhibitors on glycoprotein V hydrolysis by thrombin. Thromb Res 1984 May 01;34(3):225-31

Date

05/01/1984

Pubmed ID

6233749

DOI

10.1016/0049-3848(84)90006-9

Scopus ID

2-s2.0-0021270610 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

Platelet membrane glycoprotein V ( GPV ) is hydrolyzed during thrombin-induced platelet aggregation. The present studies were undertaken to determine whether cleavage of GPV was a direct result of thrombin action or was secondary to platelet activation. Acetylsalicylic acid or vincristine had little or no effect on platelet activation or cleavage of GPV by thrombin. Prostacyclin or antimycin A and 2-deoxyglucose inhibited platelet activation but had no effect on hydrolysis of GPV . These findings suggest that the hydrolysis of GPV occurs independently of the biochemical and morphological changes associated with platelet activation and is therefore a direct effect of thrombin.

Author List

Knupp CL, White GC 2nd

Author

Gilbert C. White MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antimycin A
Aspirin
Deoxyglucose
Epoprostenol
Glycoproteins
Humans
Hydrolysis
Membrane Proteins
Platelet Aggregation
Platelet Membrane Glycoproteins
Thrombin
Vincristine