Serologically documented loracarbef (Lorabid)-induced immune thrombocytopenia. Am J Hematol 2003 May;73(1):41-3
Date
04/18/2003Pubmed ID
12701119DOI
10.1002/ajh.10307Scopus ID
2-s2.0-0037404598 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
We report here the first case of severe immune thrombocytopenia induced by a second-generation cephalosporin antibiotic, Loracarbef. A 56-year old white female developed acute severe thrombocytopenia associated with acute respiratory symptoms following administration of Loracarbef. She responded to Loracarbef withdrawal and systemic corticosteroid administration. Loracarbef-dependent platelet-reactive antibodies were demonstrable in her serum by flow cytometry.
Author List
Aljitawi OS, Krishnan K, Curtis BR, Bougie DW, Aster RHAuthor
Brian Curtis PhD Director in the Platelet & Neutrophil Immunology Laboratory department at BloodCenter of WisconsinMESH terms used to index this publication - Major topics in bold
AutoantibodiesBlood Platelets
Cephalosporins
Female
Flow Cytometry
Humans
Methylprednisolone
Middle Aged
Purpura, Thrombocytopenic, Idiopathic
Respiratory Tract Infections