Eptifibatide-induced acute profound thrombocytopenia presenting as refractory hypotension. Catheter Cardiovasc Interv 2003 Jan;58(1):76-9
Date
01/01/2003Pubmed ID
12508202DOI
10.1002/ccd.10392Scopus ID
2-s2.0-0037221733 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.
Author List
Rezkalla SH, Hayes JJ, Curtis BR, Aster RHAuthor
Brian Curtis PhD Director in the Platelet & Neutrophil Immunology Laboratory department at BloodCenter of WisconsinMESH terms used to index this publication - Major topics in bold
Acute DiseaseAngioplasty, Balloon, Coronary
Coronary Angiography
Female
Humans
Hypotension
Middle Aged
Myocardial Infarction
Peptides
Platelet Aggregation Inhibitors
Thrombocytopenia
Time Factors