Faculty Collaboration Database

Differences Among Current Pre-exposure Prophylaxis (PrEP) Users, Former Users, and Nonusers in a Community Sample in Two Midwestern U.S. Cities: Implications for Interventions to Promote PrEP Uptake and Adherence. AIDS Educ Prev 2025 Apr;37(2):160-172

Date

05/05/2025

Pubmed ID

40323671

DOI

10.1521/aeap.2025.37.2.160

Scopus ID

2-s2.0-105004710207 (requires institutional sign-in at Scopus site)

Abstract

Disparate rates of HIV infection among Black MSM and TGW emphasize the need for interventions designed to overcome obstacles to increasing PrEP adoption within these populations. This study compared PrEP-use groups on a variety of attitudinal and behavioral factors related to PrEP adoption. Regression analysis confirmed that current and former users demonstrated greater PrEP knowledge and communicated more frequently to friends about PrEP and its benefits than nonusers. Former users exhibited more positive attitudes and perceived less stigma regarding PrEP use than other groups. Current users reported the highest prevalence of condomless anal sex and multiple partners; conversely, former users were most often in stable monogamous relationships. Our findings are consistent with the notion of prevention-effective adherence and advance our understanding of attitudinal supports for that paradigm. This research also suggests that recruitment of former PrEP users could increase the pool of effective peer behavior-change agents in future intervention efforts.

Author List

DiFranceisco W, Quinn K, Walsh JL, Kelly JA, Amirkhanian YA, McAuliffe TL, Pearson B, Brown KD

Authors

Yuri A. Amirkhanian PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Wayne J. DiFranceisco Research Scientist II in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Jeffrey A. Kelly PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Timothy L. McAuliffe PhD Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Katherine Quinn PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Jennifer L. Walsh PhD Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Anti-HIV Agents
Female
HIV Infections
Health Knowledge, Attitudes, Practice
Homosexuality, Male
Humans
Male
Medication Adherence
Middle Aged
Midwestern United States
Pre-Exposure Prophylaxis
Sexual Behavior
Sexual Partners
Social Stigma
Surveys and Questionnaires
Young Adult