Mannose 6-phosphate receptors: new twists in the tale. Nat Rev Mol Cell Biol 2003 Mar;4(3):202-12
Date
03/04/2003Pubmed ID
12612639DOI
10.1038/nrm1050Scopus ID
2-s2.0-0037336348 (requires institutional sign-in at Scopus site) 855 CitationsAbstract
The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the endosomal-lysosomal system. During the past decade, we have started to understand the structural features of these receptors that allow them to do this job, and how the receptors themselves are sorted as they pass through various membrane-bound compartments. But trafficking of acid hydrolases is only part of the story. Evidence is emerging that one of the receptors can regulate cell growth and motility, and that it functions as a tumour suppressor.
Author List
Ghosh P, Dahms NM, Kornfeld SAuthor
Nancy M. Dahms PhD Professor in the Biochemistry department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Amino Acid MotifsAmino Acid Sequence
Animals
Cations
Cattle
Cell Division
Cell Movement
Endosomes
Golgi Apparatus
Humans
Ligands
Lysosomes
Models, Biological
Models, Molecular
Molecular Sequence Data
Protein Structure, Tertiary
Protein Transport
Receptor, IGF Type 2
