Medical College of Wisconsin
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Emerging, Uncommon, and Aggressive Pediatric Kidney Tumors: An Update and Diagnostic Pitfalls. Surg Pathol Clin 2025 Jun;18(2):269-279

Date

05/25/2025

Pubmed ID

40412826

DOI

10.1016/j.path.2024.10.004

Scopus ID

2-s2.0-85210390295 (requires institutional sign-in at Scopus site)

Abstract

Although favorable histology Wilms tumors are the most prevalent pediatric renal tumor, the remainder includes a small but diverse and important group of malignant neoplasms. Among these are diffuse anaplastic Wilms tumor, blastemal Wilms tumor, anaplastic sarcoma of kidney, and clear cell sarcoma of kidney. Given their rarity, these tumors may pose diagnostic challenges for pathologists, but accurate diagnosis is essential to ensuring these aggressive tumors are managed appropriately. This article summarizes the salient clinical, histopathological, and molecular features of these uncommon but important tumors.

Author List

Parsons LN, Treece AL

Author

Lauren Parsons MD Associate Professor in the Pathology and Laboratory Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Child
Diagnosis, Differential
Humans
Kidney Neoplasms
Sarcoma
Sarcoma, Clear Cell
Wilms Tumor