Magnetizable flow diverters can magnetically capture and retain endothelial cells to promote healing in rabbit arteries. J Neuroradiol 2025 Jun;52(4):101353
Date
05/27/2025Pubmed ID
40419181Pubmed Central ID
PMC12439130DOI
10.1016/j.neurad.2025.101353Scopus ID
2-s2.0-105006753323 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Flow diverters are effective endovascular devices used to treat intracranial aneurysms by facilitating aneurysm occlusion through endothelial growth across the aneurysm neck. Rapid endothelialization reduces complications such as thrombosis and stenosis. This technical note describes braided, magnetizable flow diverters made from stainless steel alloy 2205 (SS2205) wires designed to magnetically capture autologous blood outgrowth endothelial cells (BOECs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs). Preclinical rabbit artery deployments demonstrated successful magnetic capture and retention of SPION-labeled BOECs, indicating feasibility for accelerated endothelialization. Detailed technical specifications provided in this manuscript ensure precise reproducibility, aiding future studies exploring advanced endothelialization strategies in neuroradiology.
Author List
Oliver AA, Ognard J, Cortese J, Bayraktar EA, Zielonka AM, Kallmes DF, Tefft BJ, Kadirvel RAuthor
Brandon J. Tefft PhD Associate Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsEndothelial Cells
Endovascular Procedures
Intracranial Aneurysm
Magnetite Nanoparticles
Rabbits
Stents
