The Landmark Series: Surgical Management of Functioning and Non-Functioning Pancreatic Neuroendocrine Tumors. Ann Surg Oncol 2025 Jul;32(7):4720-4728
Date
05/04/2025Pubmed ID
40319207Pubmed Central ID
PMC12130066DOI
10.1245/s10434-025-17390-xScopus ID
2-s2.0-105004201463 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Pancreatic neuroendocrine tumors (PNETs) are comparatively rare pancreatic malignancies that exhibit diverse biologic behavior, ranging from indolent tumors to widely metastatic cancers, with up to 15 % secreting hormones that cause symptoms. As a consequence, the management of PNETs is highly individualized and can include active surveillance of small (1-2 cm) and very small (< 1 cm) nonfunctioning tumors without worrisome features, parenchymal-sparing resection of appropriately located tumors, anatomic pancreatectomy and, in select cases, debulking of metastatic disease, particularly in the liver. This review synthesizes society recommendations and contemporary evidence guiding the surgical management of PNETs. Innovations in molecular profiling and systemic therapies hold promise to refine surgical algorithms for this heterogeneous tumor.
Author List
Tobias J, Clarke CN, Gangi A, Keutgen XMAuthor
Callisia N. Clarke MD Chief, Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
HumansNeuroendocrine Tumors
Pancreatectomy
Pancreatic Neoplasms
Practice Guidelines as Topic
Prognosis
