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Retinal neovascular markers in retinopathy of prematurity: aetiological implications. Br J Ophthalmol 2003 Mar;87(3):275-8



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Scopus ID

2-s2.0-0037341655 (requires institutional sign-in at Scopus site)   7 Citations


AIM: (1) To determine if expression of the blood-tissue barrier associated glucose transporter GLUT1 is preserved by the neovasculature of retinopathy of prematurity (ROP), in contrast with the reported loss of GLUT1 expression in preretinal vessels of proliferative diabetic retinopathy. (2) To compare the vascular immunophenotype of ROP to juvenile haemangioma, another perinatal neovascular disorder that has recently been shown to express placental type vascular antigens, including GLUT1 and Lewis Y antigen.

METHODS: A retrospective case report was carried out. Immunoreactivities for GLUT1 and Lewis Y antigen were assessed in a human eye with stage 3 ROP and compared with those in a control (paediatric) eye. The presence or absence of endothelial GLUT1 and Lewis Y immunoreactivity was determined in preretinal and intraretinal vessels.

RESULTS: Immunoreactivity was positive for GLUT1 and negative for Lewis Y in the intraretinal and preretinal neovasculature of the ROP affected eye and in the normal retinal vessels of the control eye.

CONCLUSIONS: Retention of immunoreactivity for GLUT1 distinguishes ROP from proliferative diabetic retinopathy. Furthermore, absence of Lewis Y antigen co-expression distinguishes ROP from juvenile haemangioma, a perinatal form of GLUT1 positive neovascularisation that has recently been linked to placental vasculature.

Author List

North PE, Anthony DC, Young TL, Waner M, Brown HH, Brodsky MC


Paula E. North MD, PhD Professor in the Pathology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Blood-Retinal Barrier
Diabetic Retinopathy
Diagnosis, Differential
Fatal Outcome
Glucose Transporter Type 1
Infant, Newborn
Monosaccharide Transport Proteins
Retinal Neovascularization
Retinal Vessels
Retinopathy of Prematurity
Retrospective Studies