Faculty Collaboration Database

Predictors of Permanent and Temporary Motor Deficits in Patients Undergoing Glioma Resection: A Systematic Review and Meta-Analysis. World Neurosurg 2025 Aug;200:124200

Date

06/28/2025

Pubmed ID

40578428

DOI

10.1016/j.wneu.2025.124200

Scopus ID

2-s2.0-105011488728 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

OBJECTIVE: To identify predictors of permanent and temporary motor deficits in patients undergoing glioma resection.

METHODS: A literature search accessed the databases Ovid Medline, Scopus, Web of Science, Cumulative Index to Nursing and Allied Health Literature/EBSCO, PsychInfo, Cochrane, and Wiley for studies reporting motor outcomes following surgical resection of glioma. Outcomes were stratified by patient/tumor characteristics, preoperative condition, and intraoperative factors for both permanent and temporary motor deficits. Generalized estimating equations were used to generate odds ratios.

RESULTS: A total of 1332 titles and abstracts were reviewed resulting in the evaluation of 261 full-text articles. Data were extracted from 67 studies including 2616 patients with 371 (14%) developing permanent postoperative motor deficits, 465 (18%) developing temporary deficits, and the remaining 1780 (68%) having no deficit. Preoperative deficit was the most significant predictor of permanent postoperative motor deficit (odds ratio [OR] 6.40, confidence interval [CI] 2.82-14.5, P < 0.0001), while high preoperative Karnofsky Performance Scale (OR 0.98, CI 0.97-0.99, P < 0.001) and subcortical tumor location (OR 0.14, C 0.030-0.62, P = 0.001) had a lower odds of a permanent deficit. Intraoperative motor-evoked potential changes was a significant predictor of both permanent (OR 5.18, CI 1.99-13.5, P = 0.00075) and temporary (OR 9.44, CI 2.78-32.0, P = 0.0003) motor deficits.

CONCLUSIONS: Preoperative motor deficits were the most significant predictors of persistent or worsening postoperative motor deficits. Intraoperative motor-evoked potential changes were associated with both permanent and temporary deficits. High Karnofsky Performance Scale and subcortical tumor location had lower odds of permanent motor deficits.

Author List

Conway BJ, Armstrong SA, Botros N, Tarima S, Krucoff MO

Author

Max O. Krucoff BS, MD Associate Professor in the Neurosurgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Brain Neoplasms
Glioma
Humans
Motor Disorders
Neurosurgical Procedures
Postoperative Complications