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Dermatologic manifestations of Crohn disease in children: response to infliximab. J Pediatr Gastroenterol Nutr 2003 Aug;37(2):150-4

Date

07/29/2003

Pubmed ID

12883301

DOI

10.1097/00005176-200308000-00013

Scopus ID

2-s2.0-1542707085   81 Citations

Abstract

Dermatologic extraintestinal manifestations of Crohn disease may be refractory to treatment with corticosteroids and immunomodulators. The authors describe four children with Crohn disease with dermatologic manifestations: pyoderma gangrenosum, orofacial involvement, erythema nodosum, and idiopathic lymphedema. These dermatologic conditions were unresponsive to conventional therapy but had rapid and sustained response to the anti-TNF-alpha antibody infliximab. No adverse reactions occurred. Infliximab should be considered for treating the extraintestinal dermatologic manifestations of Crohn disease in children.

Author List

Kugathasan S, Miranda A, Nocton J, Drolet BA, Raasch C, Binion DG

Authors

Adrian Miranda MD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin
James J. Nocton MD Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Antibodies, Monoclonal
Child
Crohn Disease
Dermatologic Agents
Erythema Nodosum
Humans
Infliximab
Lymphedema
Male
Pyoderma Gangrenosum
Treatment Outcome