Localized Sustained Release of Copper Enhances Antitumor Effects of Disulfiram in Head and Neck Cancer. Biomacromolecules 2024 May 13;25(5):2770-2779
Date
04/30/2024Pubmed ID
38687975Pubmed Central ID
PMC11143945DOI
10.1021/acs.biomac.3c01420Scopus ID
2-s2.0-85192159789 (requires institutional sign-in at Scopus site)Abstract
Drug repurposing uses approved drugs as candidate anticancer therapeutics, harnesses previous research and development efforts, and benefits from available clinically suitable formulations and evidence of patient tolerability. In this work, the drug used clinically to treat chronic alcoholism, disulfiram (DSF), was studied for its antitumor efficacy in a copper-dependent manner. The combination of DSF and copper could achieve a tumor cell growth inhibition effect comparable to those of 5-fluorouracil and taxol on head and neck cancer cells. Both bulk dendrimer hydrogel and microsized dendrimer hydrogel particles were utilized for the localized sustained release of copper in the tumor site. The localized sustained release of copper facilitated the tumor inhibition effect following intratumoral injection in a mouse's head and neck cancer model.
Author List
Wang J, Li B, Cooper RC, Huang D, Yang HAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Cell Line, Tumor
Copper
Delayed-Action Preparations
Disulfiram
Head and Neck Neoplasms
Humans
Mice
Mice, Nude
Xenograft Model Antitumor Assays
