Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release. Colloids Surf B Biointerfaces 2018 May 01;165:144-149
Date
02/25/2018Pubmed ID
29476924Pubmed Central ID
PMC5882578DOI
10.1016/j.colsurfb.2018.02.032Scopus ID
2-s2.0-85042385739 (requires institutional sign-in at Scopus site) 47 CitationsAbstract
In this work, we developed a new class of branched polyrotaxane hydrogel made of 4-arm polyethylene glycol (4-PEG) and α-cyclodextrin (α-CD) using supramolecular host-guest interactions as a cross-linking strategy. Because of the dynamic nature of the non-covalent host-guest cross-linking, the resulting supramolecular α-CD/4-PEG hydrogels show thixotropic behavior and undergo a reversible gel-sol transition in response to shear stress change. We loaded the antiglaucoma drug brimonidine into the α-CD/4-PEG gel and found the drug release kinetics was controlled by shear stress. This thixotropic shear thinning property makes the supramolecular hydrogels highly attractive in drug delivery applications and suitable for preparation of injectable drug formulations.
Author List
Wang J, Williamson GS, Yang HAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Brimonidine TartrateChemical Phenomena
Cyclodextrins
Delayed-Action Preparations
Drug Liberation
Hydrogels
Kinetics
Molecular Weight
Poloxamer
Polyethylene Glycols
Rheology
Rotaxanes
alpha-Cyclodextrins
