Folate-mediated chemotherapy and diagnostics: An updated review and outlook. J Control Release 2017 Apr 28;252:73-82
Date
02/27/2017Pubmed ID
28235591Pubmed Central ID
PMC5479736DOI
10.1016/j.jconrel.2017.02.023Scopus ID
2-s2.0-85015451755 (requires institutional sign-in at Scopus site) 100 CitationsAbstract
Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.
Author List
Xu L, Bai Q, Zhang X, Yang HAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAntineoplastic Agents
Drug Delivery Systems
Drug Liberation
Folate Receptors, GPI-Anchored
Folic Acid
Humans
Molecular Probes
Molecular Targeted Therapy
Nanoparticles
Neoplasms
Theranostic Nanomedicine
