Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing. J Biomed Mater Res A 2016 Oct;104(10):2456-65
Date
05/21/2016Pubmed ID
27199211Pubmed Central ID
PMC5108242DOI
10.1002/jbm.a.35783Scopus ID
2-s2.0-84983657288 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam's rheological, morphological, porous, and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 h. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity necessary to be a candidate material in wound dressing development. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2456-2465, 2016.
Author List
Aduba DC Jr, An SS, Selders GS, Wang J, Andrew Yeudall W, Bowlin GL, Kitten T, Yang HAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnti-Infective Agents
Bacteria
Bacterial Infections
Bandages
Biocompatible Materials
Delayed-Action Preparations
Freeze Drying
Horseradish Peroxidase
Humans
Hydrogen Peroxide
Mice
NIH 3T3 Cells
Porosity
Silver
Wound Healing
Xylans
Zea mays
