The effect of photoinitiators on intracellular AKT signaling pathway in tissue engineering application. Biomater Sci 2015 Feb;3(2):250-5
Date
02/25/2015Pubmed ID
25709809Pubmed Central ID
PMC4335638DOI
10.1039/C4BM00245HScopus ID
2-s2.0-84921649940 (requires institutional sign-in at Scopus site) 46 CitationsAbstract
Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.
Author List
Xu L, Sheybani N, Yeudall WA, Yang HAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetophenonesCell Survival
Photochemistry
Polymerization
Proto-Oncogene Proteins c-akt
Signal Transduction
Tissue Engineering
Tissue Scaffolds
Ultraviolet Rays
