Faculty Collaboration Database

Polyamidoamine dendrimer hydrogel for enhanced delivery of antiglaucoma drugs. Nanomedicine 2012 Jul;8(5):776-83

Date

09/21/2011

Pubmed ID

21930109

DOI

10.1016/j.nano.2011.08.018

Scopus ID

2-s2.0-84862645239 (requires institutional sign-in at Scopus site)   126 Citations

Abstract

UNLABELLED: Dendrimer hydrogel (DH), made from ultraviolet-cured polyamidoamine dendrimer G3.0 tethered with three polyethylene glycol (PEG, 12,000 Da)-acrylate chains (8.1% w/v) in pH 7.4 phosphate buffered saline (PBS), was studied for the delivery of brimonidine (0.1% w/v) and timolol maleate (0.5% w/v), two antiglaucoma drugs. DH was found to be mucoadhesive to mucin particles and nontoxic to human corneal epithelial cells. DH increased the PBS solubility of brimonidine by 77.6% and sustained the in vitro release of both drugs over 56-72 hours. As compared to eye drop formulations (PBS-drug solutions), DH brought about substantially higher human corneal epithelial cells uptake and significantly increased bovine corneal transport for both drugs. DH increased timolol maleate uptake in bovine corneal epithelium, stroma, and endothelium by 0.4- to 4.6-fold. This work demonstrated that DH can enhance the delivery of antiglaucoma drugs in multiple aspects and represents a novel platform for ocular drug delivery.

FROM THE CLINICAL EDITOR: Dendrimer hydrogel was studied as agent for simultaneous delivery of two anti-glaucoma drugs, one hydrophobic and one hydrophilic. Superiority over standard PBS-based formulation was clearly demonstrated for both drugs. The work may be a novel platform for ocular drug delivery.

Author List

Holden CA, Tyagi P, Thakur A, Kadam R, Jadhav G, Kompella UB, Yang H

Author

Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Brimonidine Tartrate
Cattle
Cell Line
Dendrimers
Drug Combinations
Drug Delivery Systems
Epithelium, Corneal
Glaucoma
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate
Ophthalmic Solutions
Quinoxalines
Timolol