Faculty Collaboration Database

Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents. Adv Drug Deliv Rev 2012 May 15;64(7):605-13

Date

12/20/2011

Pubmed ID

22178615

Pubmed Central ID

PMC3321130

DOI

10.1016/j.addr.2011.11.014

Scopus ID

2-s2.0-84859979641 (requires institutional sign-in at Scopus site)   106 Citations

Abstract

Research into the diagnosis and treatment of central nervous system (CNS) diseases has been enhanced by rapid advances in nanotechnology and an expansion in the library of nanostructured carriers. This review discusses the latest applications of nanomaterials in the CNS with an emphasis on brain tumors. Novel administration routes and transport mechanisms for nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents to bypass or cross the blood brain barrier (BBB) are also discussed. These include temporary disruption of the BBB, use of impregnated polymers (polymer wafers), convection-enhanced delivery (CED), and intranasal delivery. Moreover, an in vitro BBB model capable of mimicking geometrical, cellular and rheological features of the human cerebrovasculature has been developed. This is a useful tool that can be used for screening CNS nanoparticles or therapeutics prior to in vivo and clinical investigation. A discussion of this novel model is included.

Author List

Biddlestone-Thorpe L, Marchi N, Guo K, Ghosh C, Janigro D, Valerie K, Yang H

Author

Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Blood-Brain Barrier
Central Nervous System
Central Nervous System Diseases
Diagnostic Uses of Chemicals
Drug Carriers
Drug Delivery Systems
Humans
Nanoparticles
Pharmaceutical Preparations