Nanoparticle-mediated brain-specific drug delivery, imaging, and diagnosis. Pharm Res 2010 Sep;27(9):1759-71
Date
07/02/2010Pubmed ID
20593303Pubmed Central ID
PMC2933363DOI
10.1007/s11095-010-0141-7Scopus ID
2-s2.0-77955466238 (requires institutional sign-in at Scopus site) 194 CitationsAbstract
Central nervous system (CNS) diseases represent the largest and fastest-growing area of unmet medical need. Nanotechnology plays a unique instrumental role in the revolutionary development of brain-specific drug delivery, imaging, and diagnosis. With the aid of nanoparticles of high specificity and multifunctionality, such as dendrimers and quantum dots, therapeutics, imaging agents, and diagnostic molecules can be delivered to the brain across the blood-brain barrier (BBB), enabling considerable progress in the understanding, diagnosis, and treatment of CNS diseases. Nanoparticles used in the CNS for drug delivery, imaging, and diagnosis are reviewed, as well as their administration routes, toxicity, and routes to cross the BBB. Future directions and major challenges are outlined.
Author List
Yang HAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBlood-Aqueous Barrier
Central Nervous System Diseases
Dendrimers
Drug Carriers
Endothelial Cells
Ferric Compounds
Humans
Liposomes
Magnetic Resonance Imaging
Nanoparticles
Pharmaceutical Preparations
Quantum Dots
Transcytosis
