Medical College of Wisconsin
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Encapsulation and extended release of anti-cancer anastrozole by stealth nanoparticles. Drug Deliv 2008 Jun;15(5):343-6

Date

09/03/2008

Pubmed ID

18763165

DOI

10.1080/10717540802035343

Scopus ID

2-s2.0-50849109488 (requires institutional sign-in at Scopus site)   44 Citations

Abstract

To improve delivery efficiency of anastrozole, we applied dendrimer-based stealth nanoparticles to encapsulate anastrozole to formulate stealth anastrozole nanoparticles. This work demonstrated that stealth nanoparticles composed of a PAMAM dendrimers core and a PEG layer could encapsulate anastrozole, hence causing improved water solubility of anastrozole. Anastrozole encapsulation depended on concentration of stealth nanoparticles and generation of dendrimer. The extended release of anastrozole was achieved. We envisioned that this highly structurally adaptable stealth nanoparticle could be further biofunctionalized to construct a targeted therapeutic delivery system for breast cancer treatment.

Author List

Sarkar K, Yang H

Author

Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Antineoplastic Agents, Hormonal
Delayed-Action Preparations
Dendrimers
Drug Carriers
Nanoparticles
Nitriles
Particle Size
Polyamines
Polyethylene Glycols
Solubility
Surface Properties
Triazoles