Stealth dendrimers for antiarrhythmic quinidine delivery. J Mater Sci Mater Med 2007 Oct;18(10):2061-5
Date
06/15/2007Pubmed ID
17558476DOI
10.1007/s10856-007-3144-0Scopus ID
2-s2.0-34548748110 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
Dendrimers have been attracting growing attention because of their unique well-defined globular nanoscale architecture and numerous functional groups on the surface. Attachment of PEG to the dendrimer generates stealth dendrimers, which have promising structural advantages for drug delivery. In this study, synthetic methods were explored to deliver antiarrhythmic quinidine by stealth dendrimers. In particular, quinidine was covalently attached to anionic G2.5 and cationic G3.0 polyamidoamine (PAMAM) dendrimers via a glycine spacer, respectively. The resulting quinidine-PAMAM-PEG conjugates were characterized and confirmed by FT-IR and (1)H-NMR. In vitro hydrolysis was carried out in pH 7.4 PBS buffer at 37 degrees C to confirm the bioavailability of the conjugated quinidine.
Author List
Yang H, Lopina STAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Arrhythmia AgentsDendrimers
Hydrolysis
Models, Biological
Polyamines
Polyethylene Glycols
Quinidine
