Medical College of Wisconsin
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Dendrimers for pharmaceutical and biomedical applications. J Biomater Sci Polym Ed 2006;17(1-2):3-19

Date

01/18/2006

Pubmed ID

16411595

DOI

10.1163/156856206774879171

Scopus ID

2-s2.0-33746077220 (requires institutional sign-in at Scopus site)   172 Citations

Abstract

Dendrimers are a unique class of synthetic macromolecules having a highly branched, three-dimensional, nanoscale architecture with very low polydispersity and high functionality. Structural advantages allow dendrimers to play an important role in the fields of nanotechnology, pharmaceutical and medicinal chemistry. This review discusses several aspects of dendrimers, including preparation, dendrimer-drug coupling chemistry, structural models of dendrimer-based drug delivery systems, and physicochemical and toxicological properties.

Author List

Yang H, Kao WJ

Author

Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Chemical Phenomena
Chemistry, Physical
Dendrimers
Drug Carriers
Models, Biological
Molecular Weight
Nanostructures