Extended release of a novel antidepressant, venlafaxine, based on anionic polyamidoamine dendrimers and poly(ethylene glycol)-containing semi-interpenetrating networks. J Biomed Mater Res A 2005 Jan 01;72(1):107-14
Date
11/16/2004Pubmed ID
15543595DOI
10.1002/jbm.a.30220Scopus ID
2-s2.0-10344222643 (requires institutional sign-in at Scopus site) 72 CitationsAbstract
The multiple daily administration of venlafaxine, a novel third-generation antidepressant, was reduced based on polyamidoamine and polyethylene glycol (PEG)-containing semi-interpenetrating network (IPN), respectively. Venlafaxine was covalently linked to water-soluble G2.5 anionic polyamidoamine dendrimer via a hydrolyzable ester bond. Semi-IPN hydrogels were prepared by crosslinking acrylamide in the presence of PEG, and venlafaxine with predetermined amounts was loaded in situ. Dendrimer-venlafaxine conjugate and semi-IPNs were characterized by proton nuclear magnetic resonance and Fourier transform infrared, respectively. The effect of PEG concentration and molecular weight was studied and discussed for an optimal controlled release.
Author List
Yang H, Lopina STAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcrylamideAnions
Antidepressive Agents
Cyclohexanols
Delayed-Action Preparations
Hydrogels
Magnetic Resonance Spectroscopy
Molecular Weight
Permeability
Polyamines
Polyethylene Glycols
Spectroscopy, Fourier Transform Infrared
Venlafaxine Hydrochloride
