Penicillin V-conjugated PEG-PAMAM star polymers. J Biomater Sci Polym Ed 2003;14(10):1043-56
Date
12/10/2003Pubmed ID
14661878DOI
10.1163/156856203769231556Scopus ID
2-s2.0-0242269078 (requires institutional sign-in at Scopus site) 138 CitationsAbstract
Starburst PAMAM dendrimers are potential carriers for drug delivery due to their unique structure. Drug-delivery scaffolds were designed and built up based on the polyethylene glycolpolyamidoamine (PEG-PAMAM) star polymer. Penicillin V was used as a model carboxylic group containing drug to conjugate with full- and half-generation PAMAM dendrimers. G2.5 PAMAM (with 32 carboxylic groups on the surface) dendrimers and G3.0 (with 32 primary amine groups on the surface) were typically chosen. There are two strategies given in the paper where a drug carrying a carboxylic group (e.g. penicillin V) was coupled to star polymer via amide and ester bonds, respectively. FT-IR, UV-Vis and 1H-NMR were used to characterize the intermediates and drug-star polymer conjugates. A single-strain bacterium, Staphylococcus aureus, was grown up for penicillin-conjugated PEG-PAMAM (G3.0) star polymer activity test. The result verified the bioavailability of modified penicillin after the ester bond was cleaved.
Author List
Yang H, Lopina STAuthor
Hu Yang PhD Chair, Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsBiocompatible Materials
Dendrimers
Drug Delivery Systems
Magnetic Resonance Spectroscopy
Penicillin V
Polyamines
Polyethylene Glycols
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Staphylococcus aureus
