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An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control. Respir Physiol Neurobiol 2010 Oct 31;173(3):288-97

Date

03/09/2010

Pubmed ID

20206717

Pubmed Central ID

PMC2894288

DOI

10.1016/j.resp.2010.02.015

Scopus ID

2-s2.0-77954526298 (requires institutional sign-in at Scopus site)   91 Citations

Abstract

In this review we discuss the implications for ventilatory control of newer evidence suggesting that central and peripheral chemoreceptors are not functionally separate but rather that they are dependent upon one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the carotid body chemoreceptors and vice versa i.e., they are interdependent. We examine potential interactions of the interdependent central and carotid body (CB) chemoreceptors with other ventilatory-related inputs such as central hypoxia, lung stretch, and exercise. The limitations of current approaches addressing this question are discussed and future studies are suggested.

Author List

Smith CA, Forster HV, Blain GM, Dempsey JA

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Brain
Carotid Body
Chemoreceptor Cells
Humans
Models, Biological
Pulmonary Ventilation