An interdependent model of central/peripheral chemoreception: evidence and implications for ventilatory control. Respir Physiol Neurobiol 2010 Oct 31;173(3):288-97
Date
03/09/2010Pubmed ID
20206717Pubmed Central ID
PMC2894288DOI
10.1016/j.resp.2010.02.015Scopus ID
2-s2.0-77954526298 (requires institutional sign-in at Scopus site) 91 CitationsAbstract
In this review we discuss the implications for ventilatory control of newer evidence suggesting that central and peripheral chemoreceptors are not functionally separate but rather that they are dependent upon one another such that the sensitivity of the medullary chemoreceptors is critically determined by input from the carotid body chemoreceptors and vice versa i.e., they are interdependent. We examine potential interactions of the interdependent central and carotid body (CB) chemoreceptors with other ventilatory-related inputs such as central hypoxia, lung stretch, and exercise. The limitations of current approaches addressing this question are discussed and future studies are suggested.
Author List
Smith CA, Forster HV, Blain GM, Dempsey JAAuthor
Hubert V. Forster PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain
Carotid Body
Chemoreceptor Cells
Humans
Models, Biological
Pulmonary Ventilation