Disrupted Large-Scale Brain Network Connectivity in Prolonged Grief Disorder: Relationship With Grief-Related Avoidance, Yearning, and Intrusive Thoughts. Biol Psychiatry Cogn Neurosci Neuroimaging 2025 Aug 05
Date
08/07/2025Pubmed ID
40769298Pubmed Central ID
PMC12346161DOI
10.1016/j.bpsc.2025.07.011Scopus ID
2-s2.0-105020753594 (requires institutional sign-in at Scopus site) 1 CitationAbstract
BACKGROUND: Large-scale brain network dysfunctions have been implicated in multiple neuropsychiatric disorders. Disrupted interactions between these networks may similarly underlie key symptoms in prolonged grief disorder (PGD).
METHODS: In a cross-sectional functional magnetic resonance imaging study, resting-state functional connectivity (rsFC) between large-scale networks was compared in demographic- and time since loss-equated older adults with probable PGD (n = 42) and those with integrated grief (IG) (n = 45). Group independent component analysis revealed multiple networks, 8 of which (salience [SN], default mode [DMN], left and right executive control, ventral attention, dorsal attention, sensorimotor, and visual) were selected for further analyses, with rsFC strength between all network pairs computed. Networks with significant group differences were further assessed using fractional amplitude of low-frequency fluctuations (fALFF) to determine within-network differences. The relationships between connectivity measures and clinical symptoms were explored independently in the PGD and IG groups.
RESULTS: Higher rsFC between SN and DMN was observed in the PGD group compared with the IG group (pcorrected = .014), which positively correlated with grief severity (pcorrected = .04) and grief-related avoidance (pcorrected = .04). In the PGD group, higher fALFF was observed in the DMN (puncorrected = .04), but not the SN. Principal component analysis revealed 4 symptom dimensions, with connectivity between multiple brain networks extending beyond the SN and DMN associated with an intrusive thoughts/yearning/avoidance component.
CONCLUSIONS: Aberrant connectivity between the SN and DMN appears to be a neurobiological correlate of grief severity and avoidance in PGD. Broader between-network connectivity disruptions correlate with intrusive thoughts, yearning, and avoidance, warranting further investigations into the mechanistic role of brain network dysfunction in PGD.
Author List
Blair NP, Hwang G, Ward BD, Claesges SA, Webber AR, Hainsworth KR, Wang Y, Reynolds CF 3rd, Stein EA, Goveas JSAuthors
Joseph S. Goveas MBBS, MD Professor in the Psychiatry and Behavioral Medicine department at Medical College of WisconsinKeri Hainsworth PhD Director, Associate Professor in the Anesthesiology department at Medical College of Wisconsin
Gyujoon Hwang PhD Assistant Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin
Yang Wang MD Professor in the Radiology department at Medical College of Wisconsin
