Peri-implant tissue response and biodegradation performance of a Mg-1.0Ca-0.5Sr alloy in rat tibia. Mater Sci Eng C Mater Biol Appl 2016 May;62:79-85
Date
03/10/2016Pubmed ID
26952400DOI
10.1016/j.msec.2015.12.002Scopus ID
2-s2.0-84955482652 (requires institutional sign-in at Scopus site) 37 CitationsAbstract
Biodegradable magnesium (Mg) alloys combine the advantages of traditional metallic implants and biodegradable polymers, having high strength, low density, and a stiffness ideal for bone fracture fixation. A recently developed Mg-Ca-Sr alloy potentially possesses advantageous characteristics over other Mg alloys, such as slower degradation rates and minimal toxicity. In this study, the biocompatibility of this Mg-Ca-Sr alloy was investigated in a rat pin-placement model. Cylindrical pins were inserted in the proximal tibial metaphyses in pre-drilled holes orthogonal to the tibial axis. Implant and bone morphologies were investigated using μCT at 1, 3, and 6 weeks after implant placement. At the same time points, the surrounding tissue was evaluated using H&E, TRAP and Goldner's trichrome staining. Although gas bubbles were observed around the degrading implant at early time points, the bone remained intact with no evidence of microfracture. Principle findings also include new bone formation in the area of the implant, suggesting that the alloy is a promising candidate for biodegradable orthopedic implants.
Author List
Berglund IS, Jacobs BY, Allen KD, Kim SE, Pozzi A, Allen JB, Manuel MVAuthor
Josephine Allen PhD, MS Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Absorbable ImplantsAlloys
Animals
Biocompatible Materials
Bone Nails
Calcium
Hydrogen
Magnesium
Male
Materials Testing
Rats
Rats, Sprague-Dawley
Strontium
Tibia
X-Ray Microtomography
