Medical College of Wisconsin
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The Effect of Simulated Microgravity on Differentiation of Porcine Blood-Derived Vascular Stem Cells. Stem Cells Dev 2016 Feb 15;25(4):329-36

Date

12/10/2015

Pubmed ID

26649474

DOI

10.1089/scd.2015.0297

Scopus ID

2-s2.0-84958160275 (requires institutional sign-in at Scopus site)   7 Citations

Abstract

The negative effects of space flight on cardiovascular health of astronauts have been demonstrated and documented over many years. Endothelial cells (ECs) play an important role in regulating weightlessness-induced cardiovascular dysfunction. This project seeks to study the effect of microgravity on the differentiation of endothelial progenitor cells (EPCs) into ECs and the downstream functions of the differentiated cells. Initial exposure of EPCs to microgravity indicated an inhibition of migratory, proliferative, and antithrombogenic capacity of the differentiated ECs. However, our results indicate a potential recovery of proliferative and antithrombogenic functions on prolonged exposure to microgravity.

Author List

Ramaswamy V, Dirr EW, Allen JB

Author

Josephine Allen PhD, MS Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Bioreactors
Blood Vessels
Cell Differentiation
Endothelial Progenitor Cells
Leukocytes, Mononuclear
Sus scrofa
Weightlessness Simulation