Medical College of Wisconsin
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Substance P: correlation of CSF and plasma levels. Headache 1994 May;34(5):261-4

Date

05/01/1994

Pubmed ID

7517924

DOI

10.1111/j.1526-4610.1994.hed3405261.x

Scopus ID

2-s2.0-0028244929 (requires institutional sign-in at Scopus site)   14 Citations

Abstract

OBJECTIVE: To determine the correlation between cerebrospinal fluid and plasma concentrations of substance P.

PATIENTS: 37 patients undergoing lumbar puncture for various diagnostic purposes.

MEASUREMENTS: Samples of cerebrospinal fluid and blood were obtained at the same visit. Substance P was measured by radioimmunoassay technique. At least 4 separate measurements were conducted on each sample to insure accuracy.

RESULTS: The mean plasma SP level was 1.195 (+/- 1.1). The mean cerebrospinal fluid substance P level was 1.075 (+/- .07). There was a statistically significant positive correlation between substance P level in the plasma and cerebrospinal fluid. The Pearson correlation coefficient was 0.656 (P < .0001) and the Spearman correlation coefficient was 0.698 (P < .0001).

CONCLUSIONS: Plasma substance P levels closely correlate with cerebrospinal fluid substance P levels. This will simplify the measurement of substance P in the evaluation of therapeutic agents for headache.

Author List

Clark JW, Senanayake PD, Solomon GD, Gallagher C

Author

Glen D. Solomon MD Professor in the Neurology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Female
Headache
Humans
Male
Middle Aged
Radioimmunoassay
Substance P