Faculty Collaboration Database

Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution 1H magnetic resonance spectroscopy. Neurochem Res 2008 Nov;33(11):2342-9

Date

05/14/2008

Pubmed ID

18473166

DOI

10.1007/s11064-008-9739-0

Scopus ID

2-s2.0-52549113219 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

Many previous in vivo (1)H magnetic resonance spectroscopy (MRS) studies have shown that patients with major depressive disorder (MDD) are associated with perturbations of cerebral metabolism of neurotransmitters glutamate (Glu) and gamma-aminobutyric acid (GABA). In this study, we investigated the changes of cerebral metabolism in a depression-like rat model of chronic forced swimming stress (CFSS). The aims are to further understand the pathophysiological mechanisms underlying CFSS treatment, and to further establish the face and predictive validity of the CFSS model. The results showed that, relative to control, the CFSS rats had significantly reduced Glu, taurine and glutamate + glutamine (Glx) levels in the PFC, and significantly reduced N-acetyl aspartate (NAA) level, Glu level and Glu/GABA ratio in the hippocampus. Taking together, these results suggest that CFSS treatment can induce region-specific changes in the metabolism of Glu. The CFSS model might be used to study antidepressants specifically targeting the central glutamatergic system.

Author List

Li CX, Wang Y, Gao H, Pan WJ, Xiang Y, Huang M, Lei H

Author

Yaqiang Wang PhD, MS Assistant Professor in the Biophysics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Behavior, Animal
Brain
Depression
Glutamic Acid
Magnetic Resonance Spectroscopy
Male
Rats
Rats, Wistar
Stress, Physiological
Swimming
gamma-Aminobutyric Acid