Functional recovery after facial nerve crush is delayed in severe combined immunodeficient mice. Brain Behav Immun 2002 Dec;16(6):808-12
Date
12/14/2002Pubmed ID
12480509DOI
10.1016/s0889-1591(02)00017-xScopus ID
2-s2.0-12244251838 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
The goal of the current study was to determine if T and B lymphocytes play a role in functional recovery after peripheral nerve injury. The time course of behavioral recovery following facial nerve crush injury at the stylomastoid foramen was established in scid mice which lack functional T and B cells and reconstituted scid mice as compared to wild-type mice. The average time necessary for recovery of full eye blink reflex and vibrissae movements in wild-type mice was 10.3+/-0.2 and 9.9+/-0.34 days, respectively. In contrast, recovery of full eye blink reflex and vibrissae movements took 14.8+/-0.54 and 12.3+/-0.41 days, respectively, in scid mice. Reconstitution of scid mice with whole splenocytes resulted in functional recovery times similar to wild-type, with eye blink reflex recovery and vibrissae movement being 10.5+/-0.3 and 10.0+/-0.0 days, respectively. These results suggest that the delayed behavioral recovery time observed in scid mice may be due to the absence of T and B lymphocytes.
Author List
Serpe CJ, Tetzlaff JE, Coers S, Sanders VM, Jones KJAuthor
Julie Tetzlaff PhD Associate Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsB-Lymphocytes
Behavior, Animal
Cell Survival
Facial Nerve Injuries
Female
Mice
Mice, Inbred ICR
Mice, SCID
Motor Neurons
Nerve Crush
Nerve Regeneration
Neuroimmunomodulation
Recovery of Function
T-Lymphocytes
