Enhanced norepinephrine sensitivity in renal arteries at elevated transmural pressure. Am J Physiol 1990 Jul;259(1 Pt 2):H29-33
Date
07/01/1990Pubmed ID
2375412DOI
10.1152/ajpheart.1990.259.1.H29Scopus ID
2-s2.0-0024991327 (requires institutional sign-in at Scopus site) 46 CitationsAbstract
The electrical and mechanical responses of vascular smooth muscle to norepinephrine were compared at three different levels of transmural pressure (60, 100, and 140 mmHg) in cannulated small arteries that were isolated from dog kidneys. Elevation of transmural pressure caused depolarization of the vascular smooth muscle and a significant increase in vessel sensitivity to norepinephrine. Norepinephrine produced less depolarization as transmural pressure was elevated. Comparison of the relationship between transmembrane potential and norepinephrine concentration at these different transmural pressures suggests that membrane depolarization contributes to, but is not the sole explanation of, the increased norepinephrine sensitivity at higher transmural pressures. The results of this study suggest that transmural pressure in a blood vessel may be an important determinant of its sensitivity to vasoactive agonists.
Author List
Lombard JH, Eskinder H, Kauser K, Osborn JL, Harder DRMESH terms used to index this publication - Major topics in bold
AnimalsBlood Pressure
Cell Membrane
Dogs
Hypertension, Renal
Membrane Potentials
Muscle, Smooth, Vascular
Norepinephrine
Renal Artery