Choline acetyltransferase activity parallels the pressure gradient in the feline pharyngo-esophageal region. Auton Neurosci 2001 Jun 20;89(1-2):125-7
Date
07/28/2001Pubmed ID
11474640DOI
10.1016/S1566-0702(01)00248-XScopus ID
2-s2.0-0035919229 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Pressures generated by the pharyngeal constrictor muscles and proximal esophagus involve acetylcholine-induced muscle contractions. We hypothesized that the pharyngo-esophageal pressure gradient is related to choline acetyltransferase activity. In nine anesthetized cats, hypopharyngeal pressure and proximal esophageal pressure were recorded with a solid state transducer assembly. Enzymatic activities in the thyropharyngeus, cricopharyngeus, and proximal esophageal muscles were measured. Hypopharyngeal pressure was higher than the proximal esophagus (p < 0.01), and choline acetyltransferase activity was higher in the cricopharyngeus compared to the proximal esophagus ( p < 0.05). The pressure gradient between the hypopharynx and proximal esophagus may be influenced by the activity of choline acetyltransferase.
Author List
Xie P, Medda B, Ren J, Mustin E, Shaker R, Koch TRAuthor
Reza Shaker MD Assoc Provost, Sr Assoc Dean, Ctr Dir, Chief, Prof in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AcetylcholinesteraseAnimals
Cats
Choline O-Acetyltransferase
Deglutition
Esophagus
Pharynx
Pressure
Vagus Nerve