Primate amnion development. Development 2024 Dec 01;152(23)
Date
11/26/2025Pubmed ID
41294309Pubmed Central ID
PMC12701618DOI
10.1242/dev.204621Scopus ID
2-s2.0-105023023527 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Formation of the amnion in humans is crucial for fetal development and a healthy pregnancy. In addition to providing a protective layer to the developing fetus as a component of the amniochorionic fetal membranes, the amnion serves as a signaling center for patterning early embryonic tissues. However, because the amnion is first specified in the human epiblast during implantation, the molecular and cellular events of this early amniogenic process in humans cannot be studied in utero. Recent developments using new human stem cell-derived model systems, as well as single-cell and spatial transcriptomic analyses of early human and monkey embryos, have uncovered new insights into the underpinnings of primate amnion specification. Here, we highlight recent findings from human and monkey models with an emphasis on current understandings of morphogenesis, BMP-driven transcriptional signatures and key players associated with primate amniotic ectoderm specification.
Author List
Sekulovski N, Carleton AE, Lin CW, Taniguchi KAuthor
Chien-Wei Lin PhD Associate Professor in the Data Science Institute department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AmnionAnimals
Bone Morphogenetic Proteins
Female
Gene Expression Regulation, Developmental
Humans
Morphogenesis
Pregnancy
Primates
Signal Transduction
