Expanding the Use of Ex Situ Organ Machine Perfusion Beyond Transplantation. Artif Organs 2025 Aug;49(8):1229-1235
Date
04/22/2025Pubmed ID
40259786DOI
10.1111/aor.15011Scopus ID
2-s2.0-105003300733 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Machine perfusion preservation of grafts has become the gold standard organ preservation method. It has been developed to improve the quality of grafts due to the increasing gap between demand and supply of organs for transplantation. Following successful long-term machine perfusion preservation with automated commercial devices developed for preservation of organs for transplantation, there is increasing interest in utilizing perfused discarded human organs and xenografts for a variety of purposes beyond transplantation including gene therapy and modulation, drug testing, chemotherapy, ex vivo surgery, organ supporting systems, bioengineering, and surgical training and education. Here, we review all current and potential applications of machine perfusion preservation.
Author List
Martins PN, Edil BH, McNally L, Battula NRAuthor
Narendra Battula MD Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHumans
Organ Preservation
Organ Transplantation
Perfusion
