Successful Liver Transplant From a Donor With Sickle Cell Disease. Am Surg 2024 Dec;90(12):3301-3304
Date
07/26/2024Pubmed ID
39056458DOI
10.1177/00031348241268273Scopus ID
2-s2.0-85206959033 (requires institutional sign-in at Scopus site)Abstract
Sickle cell disease patients have routinely been excluded from liver transplant donation due to patients historically manifesting liver disease themselves. Marginal donors have become increasingly more welcome given organ shortage. Our institution performed a liver transplant in a recipient with cholangiocarcinoma using a sickle cell disease donor liver. Postoperatively, patient progressed well and is now cancer free. Pathology indicated sickle cells, and hemosiderin present at time of transplant had largely resolved by repeat biopsy on postoperative day 5. We conclude that sickle cell disease patients should be considered as donors for liver transplant in the appropriate setting.
Author List
Pardue K, Timmerman M, Elgenaid S, Hassell L, Battula NR, Pitchaimuthu MAuthor
Narendra Battula MD Associate Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAnemia, Sickle Cell
Bile Duct Neoplasms
Cholangiocarcinoma
Female
Humans
Liver Transplantation
Male
Middle Aged
Tissue Donors
