Thrombotic microangiopathy associated with mantle cell lymphoma: a case report. BMC Nephrol 2025 Nov 03;26(1):611
Date
11/04/2025Pubmed ID
41184788Pubmed Central ID
PMC12581422DOI
10.1186/s12882-025-04547-9Scopus ID
2-s2.0-105020750951 (requires institutional sign-in at Scopus site)Abstract
BACKGROUND: Thrombotic microangiopathy (TMA) is a syndrome characterized by vascular endothelial cell damage, with anemia, thrombocytopenia, and thrombus-related organ damage. Secondary TMA is caused by various factors, including hematological malignancy. Case reports on TMA with mantle cell lymphoma (MCL) are extremely rare. Herein, we report a case of secondary TMA wherein MCL was diagnosed based on the same kidney biopsy specimen and treated with chemotherapy, resulting in improvement in TMA.
CASE PRESENTATION: A 60-year-old man was admitted to our hospital for acute kidney injury with TMA and focal interstitial lymphocytic infiltration, which was detected by kidney biopsy performed at a previous hospital. Plasma exchange, hemodialysis, and steroid therapy were initiated; however, the TMA did not improve. Immunostaining of the kidney biopsy specimen revealed MCL; chemotherapy was initiated, which improved the thrombocytopenia and hemolysis.
CONCLUSIONS: To our best knowledge, this is a very rare case of secondary TMA owing to MCL wherein chemotherapy was effective, suggesting a causal relationship. Kidney biopsy was key to identifying the underlying malignancy.
Author List
Tonouchi Y, Hashimoto K, Iwabuchi R, Sakai H, Nimura T, Yamaka K, Nishikawa M, Yamaguchi A, Sonoda K, Kamijo YAuthor
Kosuke Yamaka Postdoctoral Researcher in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Acute Kidney InjuryHumans
Kidney
Lymphoma, Mantle-Cell
Male
Middle Aged
Thrombotic Microangiopathies
