Fatal case of cryptogenic organizing pneumonia associated with everolimus. Ann Saudi Med 2014;34(5):437-9
Date
04/02/2015Pubmed ID
25827702Pubmed Central ID
PMC6074550DOI
10.5144/0256-4947.2014.437Scopus ID
2-s2.0-84929321130 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Noninfectious pneumonitis (NIP) has been reported with everolimus; however, the majority of the reported cases were mild to moderate. We report a fatal case of cryptogenic organizing pneumonia (COP) in a 61-year-old man. About 4 weeks after starting everolimus, the patient was admitted to the hospital with complaints of a 1-week history of progressive dyspnea with exertion and cough. The chest radiograph showed bilateral multifocal dense opacities, and he was started on antibiotics. However, his respiratory status deteriorated, and he was subsequently intubated and transferred to the intensive care unit. Chest computed tomography showed bronchocentric consolidation associated with widespread bilateral fine reticular opacification. Video-assisted thoracoscopic lung biopsy showed noncaseating granulomatous inflammation and features of COP. All cultures were negative for bacterial, viral, and fungal infections. Despite discontinuing everolimus and initiating corticosteroids, the patient died of progressive respiratory failure secondary to COP.
Author List
Nazer L, Alnajjar T, Salah S, Khzouz J, Alfaqeer N, Qandeel MAuthor
Monther Qandeel MBChB Assistant Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Carcinoma, Renal CellCryptogenic Organizing Pneumonia
Everolimus
Fatal Outcome
Humans
Immunosuppressive Agents
Kidney Neoplasms
Male
Middle Aged
Radiography
Sirolimus
