Faculty Collaboration Database

Study design and methodologies for the men moving forward lifestyle intervention trial with black prostate cancer survivors. Contemp Clin Trials 2026 Feb;161:108205

Date

12/27/2025

Pubmed ID

41453520

Pubmed Central ID

PMC12987546

DOI

10.1016/j.cct.2025.108205

Scopus ID

2-s2.0-105027232337 (requires institutional sign-in at Scopus site)

Abstract

BACKGOUND: Prostate cancer (PC) incidence and mortality rates are significantly higher among Black/African-American (Black) men compared to men of other race/ethnicities. Comorbidities and compromised quality of life are also greater challenges for this community of men. Many factors drive these differences among which body composition and health behaviors are important, yet modifiable contributors. Lifestyle interventions report beneficial results for PC survivors; however, the inclusion of Black men is critically limited. This paper describes Men Moving Forward (MMF) -a community-based lifestyle intervention for Black men with PC.

METHODS/DESIGN: This trial will randomize (1:1) 200 Black men with PC who completed treatment or are on active surveillance. The 16-week MMF intervention, conducted in partnership with the Milwaukee Recreation system, supports adoption of the American Cancer Society Nutrition and Physical Activity guidelines. Measures of body composition (primary), behavior (diet, physical activity), fitness, quality of life, and biomarkers of general health and PC recurrence risk are collected at baseline, post-intervention and at a 12-month follow-up. The primary hypothesis is that men receiving the MMF intervention will exhibit greater changes in body composition than those in the wait-list control group.

DISCUSSION: The MMF trial addresses an important gap in the current literature, evaluating the potential efficacy of a lifestyle program developed with and for Black men with PC. Outcomes including body composition and biomarkers of general health and PC recurrence risk add to our knowledge and methodologies on health behaviors and PC survivorship. Study results will inform survivorship efforts for this high-risk, underrepresented population. U.S.

CLINICALTRIALS: gov number: NCT03971591, 06.01.2019.

Author List

Awoyinka I, Sheean P, Papanek P, Flynn KE, Bylow K, Kilari D, Gann P, Banerjee A, Stolley M

Authors

Iwalola A. Awoyinka Assistant Professor in the Medicine department at Medical College of Wisconsin
Anjishnu Banerjee PhD Associate Professor in the Data Science Institute department at Medical College of Wisconsin
Kathryn A. Bylow MD Associate Professor in the Medicine department at Medical College of Wisconsin
Kathryn Eve Flynn PhD Vice Chair, Professor in the Medicine department at Medical College of Wisconsin
Deepak Kilari MD Associate Professor in the Medicine department at Medical College of Wisconsin
Paula Papanek PhD, MPT, LAT, FACSM Associate Professor & Director of Exercise Science in the Exercise Science & Physical Therapy department at Marquette University

MESH terms used to index this publication - Major topics in bold

Aged
Body Composition
Cancer Survivors
Diet
Exercise
Health Behavior
Humans
Life Style
Male
Middle Aged
Prostatic Neoplasms
Quality of Life
Randomized Controlled Trials as Topic
Research Design