Surgical Management of a Glioma-Associated Oncogene 1-Altered Mesenchymal Neoplasm Surrounding the Calcaneus: A Case Report. JBJS Case Connect 2026 Jan 01;16(1)
Date
01/15/2026Pubmed ID
41538469DOI
e25.00530Scopus ID
2-s2.0-105027617182 (requires institutional sign-in at Scopus site)Abstract
CASE: A 23-year-old male with no medical history presented with a painless, slowly enlarging heel mass present for 5 years. Physical examination revealed a firm lesion with mild varicosities. Magnetic resonance imaging demonstrated a 4.3 × 1.7 × 4.2-cm lobular mass with peripheral enhancement. Advanced molecular workup confirmed a glioma-associated oncogene 1 (GLI1)-altered mesenchymal neoplasm-a rare, emerging tumor with evolving classification and diagnostic challenges. The mass was widely excised with negative margins, followed by free-flap reconstruction.
CONCLUSION: GLI1-altered neoplasms are rare, unpredictable tumors requiring meticulous resection and multidisciplinary surveillance. This novel presentation from the subcutaneous soft tissue surrounding the calcaneus supports adequate excision and surveillance involving patient-specific considerations.
Author List
Kodra JD, Kleven A, Kovacs SK, Wooldridge AN, Neilson JCAuthors
John C. Neilson MD Associate Professor in the Orthopaedic Surgery department at Medical College of WisconsinAdam Neal Wooldridge MD, MPH Assistant Professor in the Orthopaedic Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
CalcaneusHumans
Magnetic Resonance Imaging
Male
Soft Tissue Neoplasms
Young Adult
Zinc Finger Protein GLI1
