Runx1 in Postn-Expressing Fibroblasts But Not Cardiomyocytes Exacerbates Adverse Cardiac Remodeling Post-Myocardial Infarction. JACC Basic Transl Sci 2026 Feb;11(2):101455
Date
01/15/2026Pubmed ID
41534459Pubmed Central ID
PMC12830150DOI
10.1016/j.jacbts.2025.101455Scopus ID
2-s2.0-105027428206 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Runx1 is strongly induced in the heart after acute injury and in chronic disease settings. Its expression negatively correlates with outcomes, and past work demonstrates a protective effect when Runx1 is inhibited through a variety of experimental means. We sought to establish which Runx1-expressing cell type(s) are responsible for the adverse remodeling phenotypes observed upon its induction. Using distinct Cre drivers, we ablated Runx1 from cardiomyocytes and fibroblasts. Following experimental myocardial infarction, we established that loss of Runx1 in fibroblasts, but not cardiomyocytes, is able to protect from adverse remodeling.
Author List
Akins KA, Arkatkar A, Flinn MA, Sandor N, Purdy AL, Brusacoram AL, Swift SK, Buday S, Choudhury P, Cui M, Lin BL, O'Meara CC, Patterson MAuthors
Priyanka Choudhury Postdoctoral Researcher 3 in the Pediatrics department at Medical College of WisconsinMichael Andrew Flinn PhD, BS, MS Instructor in the Physiology department at Medical College of Wisconsin
Brian L. Lin PhD Assistant Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of Wisconsin
Michaela Patterson PhD Associate Professor in the Cell Biology Neurobiology and Anatomy department at Medical College of Wisconsin
