Medical College of Wisconsin
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Chlorpromazine attenuates the pulmonary vascular response to isocapneic alveolar hypoxia in piglets. Dev Pharmacol Ther 1990;14(4):238-44

Date

01/01/1990

Pubmed ID

2397677

Abstract

We investigated the cardiovascular effects of chlorpromazine (CPZ) during normoxia and during alveolar hypoxia (HYP) in 9 chronically instrumented piglets aged 10-14 days. Each animal was instrumented for measurements of pulmonary and systemic arterial and left atrial pressures and pulmonary blood flow. Each piglet was studied three times: once during normoxia following infusions of normal saline (NS) and CPZ (1 mg/kg), once during established HYP (10% O2-2.5% CO2) following the infusion of NS and a third time during established HYP following the infusion of CPZ (1 mg/kg). CPZ did not alter any of the cardiovascular variables during normoxia but decreased the pulmonary arterial pressure and pulmonary vascular resistance during HYP. Thus, CPZ is a vasodilator in the pulmonary vascular bed of piglets, preconstricted by HYP.

Author List

Konduri GG, Fewell JE, Taylor BJ, Hill DE

Author

Girija Ganesh Konduri MD Chief, Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Blood Gas Analysis
Chlorpromazine
Hemodynamics
Hydrogen-Ion Concentration
Hypertension, Pulmonary
Hypoxia
Pulmonary Alveoli
Pulmonary Circulation
Swine
jenkins-FCD Prod-478 d1509cf07a111124a2d122fd3df854cc0b993c00