The biochemistry and physiology of S-nitrosothiols. Annu Rev Pharmacol Toxicol 2002;42:585-600
Date
01/25/2002Pubmed ID
11807184DOI
10.1146/annurev.pharmtox.42.092501.104328Scopus ID
2-s2.0-0036174890 (requires institutional sign-in at Scopus site) 368 CitationsAbstract
S-nitrosothiols are biological metabolites of nitric oxide. It has often been suggested that they represent a more stable metabolite of nitric oxide that can either be stored, or transported, although the evidence for this is sparse. There are many unanswered questions concerning how S-nitrosothiols are formed, how they are metabolized and how they elicit biological responses. These questions are highlighted by the fact that the known chemistry of nitric oxide, thiols, and S-nitrosothiols cannot serve to explain their proposed biological activities. This review attempts to highlight the gulf between our chemical understanding of S-nitrosothiols and the proposed biological activities of these compounds with respect to guanylyl cyclase-independent nitric oxide bioactivity and also the control of vascular tone.
Author List
Hogg NAuthor
Neil Hogg PhD Associate Dean, Professor in the Biophysics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHumans
Nitric Oxide
Nitric Oxide Donors
S-Nitrosoglutathione
S-Nitrosothiols
Signal Transduction
