Hydrogel screening approaches for bone and cartilage tissue regeneration. Ann N Y Acad Sci 2020 Jan;1460(1):25-42
Date
10/15/2019Pubmed ID
31608458DOI
10.1111/nyas.14247Scopus ID
2-s2.0-85076744941 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
The extracellular matrix (ECM) of bone and cartilage presents stem cells with a dynamic and complex array of biochemical and biomechanical signals that regulate proliferation and differentiation into bone and cartilage tissue-producing cells. Due to the multitude of signals present in this ECM, it is challenging to develop biomaterials that accurately recapitulate bone and cartilage tissues, thereby limiting the ability to present cells with multiple factors for enhanced biomaterial-induced osteogenic and chondrogenic differentiation. Conventional techniques to evaluate stem cell responses to engineered materials are laborious and time-consuming, and high-throughput screening techniques can address these limitations. Our review overviews developmental environments and signals present in bone and cartilage ECM, with a focus on applying hydrogel-based screening approaches to identify biomaterial environments that promote stem cell-mediated bone and cartilage tissue regeneration.
Author List
Benmassaoud MM, Gultian KA, DiCerbo M, Vega SLAuthor
Mehdi Benmassaoud PhD, BS, MSc Postdoctoral Researcher in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBone and Bones
Cartilage
Cell Communication
Extracellular Matrix
Humans
Hydrogels
Regeneration
