Diffusion-weighted imaging of malignant ocular masses: initial results and directions for further study. AJNR Am J Neuroradiol 2012 Feb;33(2):314-9
Date
11/26/2011Pubmed ID
22116113Pubmed Central ID
PMC7964785DOI
10.3174/ajnr.A2747Scopus ID
2-s2.0-84857288184 (requires institutional sign-in at Scopus site) 49 CitationsAbstract
BACKGROUND AND PURPOSE: Ocular masses represent a spectrum of malignant tumors and benign lesions that are sometimes difficult to detect and differentiate by conventional imaging techniques. The aim of this study was to characterize a group of malignant ocular masses with DWI, with the goals of establishing reference data and identifying potential clinical applications for improved noninvasive characterization.
MATERIALS AND METHODS: With institutional review board approval, 26 malignant ocular masses in 22 patients were retrospectively analyzed. Five masses were excluded from further analysis due to nonvisualization. Fifteen retinoblastomas, 5 melanomas, and 1 highly undifferentiated carcinoma were studied. Region-of-interest analysis was performed, and the ADC of each mass was measured and also compared with a normal-appearing thalamus. Lesion thickness was measured, the amount of susceptibility artifact was qualitatively assessed and graded, and the correlation between these factors and retinoblastoma ADC was determined.
RESULTS: Retinoblastomas had an ADC of 0.93 ± 0.3 × 10(-3) mm(2)/s (mean). Melanoma had an ADC of 1.18 ± 0.16 × 10(-3) mm(2)/s. The ADC of retinoblastoma was strongly inversely correlated with lesion thickness, likely representing the effect of partial volume averaging. ADC was not correlated with the amount of subjectively determined susceptibility artifact.
CONCLUSIONS: Malignant ocular tumors were consistently characterized with DWI, though with limitations due to artifact and partial volume averaging. Additional description of DWI of ocular masses and further technical improvements may lead to a clinical role for DWI.
Author List
Sepahdari AR, Kapur R, Aakalu VK, Villablanca JP, Mafee MFAuthor
Vinay Kumar Aakalu MPH, MD Chair, Professor in the Ophthalmology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Aged, 80 and over
Child
Child, Preschool
Diffusion Magnetic Resonance Imaging
Eye Neoplasms
Female
Humans
Infant
Male
Middle Aged
Orbital Neoplasms
Retrospective Studies
Young Adult
