Potential control of gastroesophageal reflux by local modulation of transient lower esophageal sphincter relaxations. Am J Med 2001 Dec 03;111 Suppl 8A:186S-189S
Date
12/26/2001Pubmed ID
11749948DOI
10.1016/s0002-9343(01)00829-4Scopus ID
2-s2.0-0035803974 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Transient lower esophageal sphincter relaxations (TLESRs) are neurally mediated abrupt reductions in lower esophageal sphincter (LES) pressure. TLESRs are not usually associated with deglutition or secondary peristalsis but are thought to be necessary for venting swallowed air from the stomach. Their central role in acid reflux, however, makes them a compelling therapeutic target for patients with gastroesophageal reflux disease. Pharmacologic approaches for reducing TLESR frequency are being studied, but theoretically more promising are endoscopic approaches that interfere with mechanoreceptor function. Further study into the mechanisms of action of these approaches is needed, as are controlled clinical trials to define the true utility of these techniques and identify patients who will receive the most benefit.
Author List
Massey BTAuthor
Benson T. Massey MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Esophagogastric JunctionEsophagoscopy
Gastroesophageal Reflux
Humans
Muscle Relaxation
Parasympatholytics
Prognosis
Treatment Outcome